We've got another exciting Big East matchup on the college basketball schedule as the No. 7 Marquette Golden Eagles and the DePaul Blue Demons are set to tip at 9 p.m. ET on Wednesday at Fiserv Forum. Marquette is 19-6 overall and 11-1 at home, while DePaul is 3-22 overall and 0-8 on the road. The Golden Eagles are 10-4 in conference play this season and sit second in the Big East standings while DePaul are last in the league at 0-11.

Marquette has won three of the last four head-to-head meetings but DePaul has covered the spread in three of those four matchups. This time around, the Golden Eagles are favored by 25.5 points in the latest Marquette vs. DePaul odds via SportsLine consensus and the over/under is 150.5 points. Before entering any Marquette vs. DePaul picks, you'll want to see the college basketball predictions from the model at SportsLine.

The model simulates every Division I college basketball game 10,000 times. It enters Week 16 of the 2023-24 season on a 136-89 roll on all top-rated college basketball picks dating back to last season, returning nearly $2,500 for $100 players. It is also off to a sizzling 25-13 start on top-rated spread picks this season. Anyone following has seen huge returns.

The model has set its sights on DePaul-Marquette. You can head to SportsLine to see its picks. Here are several college basketball betting lines for the game:

  • Marquette vs. DePaul spread: Marquette -25.5
  • Marquette vs. DePaul over/under: 150.5 points
  • Marquette vs. DePaul money line: Marquette -8571, DePaul +2083
  • Marquette vs. DePaul picks: See picks here

What you need to know about Marquette

Marquette unfortunately witnessed the end of its eight-game winning streak on Saturday, taking a serious blow against the UConn Huskies, falling 81-53. Even though the team lost Oso Ighodaro had a solid night, scoring 14 points to go along with two steals and two blocks.

Ighodaro is averaging 14.2 points, 7.3 rebounds, 2.8 assists, 1.2 blocks and 1.0 steals per game this season and he's become a pillar during his fourth year with the program. Tyler Kolek leads the program in points (15.7), assists (7.2) and 3-point shooting (40.4%) and he'll need to have a better performance after being limited to seven points on 2-of-11 shooting against UConn.

What you need to know about DePaul

Meanwhile, DePaul's recent rough patch got a bit rougher on Saturday after their 13th straight defeat. They fell 81-70 to the Providence Friars. Despite the defeat, DePaul had strong showings from Elijah Fisher and Jaden Henley, who both scored 15 points.

Fisher was a perfect 6-for-6 from the floor and the Texas Tech transfer is now averaging 9.6 points per game on the season while shooting 52.0% from the floor. The Blue Demons rank 351st in the nation in scoring average (64.3) and 353rd in points allowed per game (80.5).

How to make Marquette vs. DePaul picks

The model has simulated Marquette vs. DePaul 10,000 times and the results are in. The model is leaning Under and it's also generated a point-spread pick that is hitting in almost 60% of simulations. You can only see the pick at SportsLine.

So who wins DePaul vs. Marquette, and which side of the spread hits nearly 60% of the time? Visit SportsLine now to find out which side of the spread you need to jump on, all from the model that is on a 25-13 roll on its top-ranked college basketball picks this season, and find out.