For the second time in three weeks, the No. 18 Michigan Wolverines (2-1) will be underdogs when they play at Michigan Stadium. The Wolverines are set to host the No. 11 USC Trojans (2-0) on Saturday at the Big House in the Big Ten opener for both programs. The Wolverines suffered a humbling 31-12 loss to Texas at home in Week 2, but bounced back nicely with a 28-18 win over Arkansas State in Week 3. The Trojans had a bye in Week 3, but have been impressive in their two wins to open the season. USC opened the season with a 27-20 win over LSU, and followed that up with a 48-0 win over Utah State. USC leads the all-time series 6-4, including a 32-18 win in the 2007 Rose Bowl in the last meeting between the powerhouse programs.
Kickoff at Michigan Stadium in Ann Arbor is scheduled for 3:30 p.m. ET on CBS and Paramount+. The Trojans are favored by 4.5 points in the latest USC vs. Michigan odds via SportsLine consensus, while the over/under is 44 points. Before making any Michigan vs. USC picks, you need to see the Week 4 college football predictions and betting advice from SportsLine's Jimmie Kaylor.
Saturday's game can be seen live on CBS and streamed live on Paramount+, which you can now get for 50% off your first year plus a 7-day free trial (valid through 9/22/24). Sign up here and get half-off.
Kaylor is an NFL, college football and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. He has his finger on the pulse of the college football landscape and has been cashing in big for the last two years.
Kaylor destroyed the books in college football in 2023, netting a whopping 57.9 units while posting a 107-45-2 record. Anyone who followed his picks finished the season way up.
Now, Kaylor has dialed in on Michigan vs. USC on Saturday and just revealed his picks and predictions. You can head to SportsLine now to see his picks. Here are the college football odds and betting lines on the spread, money line and over/under for USC vs. Michigan:
- USC vs. Michigan spread: USC -4.5
- USC vs. Michigan over/under: 44 points
- USC vs. Michigan money line: USC -188, Michigan +155
- USC vs. Michigan streaming: Paramount+
- USC vs. Michigan picks: See picks at SportsLine
Why USC can cover
USC has had two weeks to prepare for this marquee matchup. The Trojans notched an impressive win over LSU in their season opener, and followed that up with a dominant shutout win over Utah State a week later before having Week 3 off. Junior quarterback Miller Moss has been efficient and played turnover-free football in his first season as the program's full-time starter.
Lincoln Riley-led teams have never been known as defensive juggernauts, but the 2024 Trojans may be different. New defensive coordinator D'Anton Lynn has completely changed the culture for USC on that side of the ball, and the results speak for themselves. The Trojans held LSU's high-powered attack to 20 points and then shut out Utah State a week later. See which team to pick here.
Why Michigan can cover
There will be a level of uncertainty that could work in Michigan's favor when the Wolverines have the ball. After experiencing some struggles to open the season, the Wolverines are turning to junior Alex Orji at quarterback. Orji has only attempted seven passes in his three years in Ann Arbor, but two have gone for touchdowns. Orji has made his mark as a runner up to this point in his career, and his dual-threat ability adds a new dimension to Michigan's offense.
The Wolverines once again have one of the best defenses in college football. Cornerback Will Johnson is arguably the best defensive back in the country, and is a strong contender to win the 2024 Jim Thorpe Award. Junior defensive tackles Mason Graham and Kenneth Grant are both future NFL Draft picks and give the Wolverines one of the best defensive interiors in the country. See which team to pick here.
How to make Michigan vs. USC picks
Kaylor has analyzed USC vs. Michigan from every angle and he's leaning Over on the point total. He has also discovered a critical X-factor that has him jumping all over one side of the spread. He's only sharing what it is, and which side to back, at SportsLine.
So who wins Michigan vs. USC in Ann Arbor on Saturday, and what critical X-factor makes one side of the spread a must back? Visit SportsLine now to see which side of the spread to jump on, all from the expert who profited $5,790 for $100 college football bettors in 2023, and find out.
