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| The Eagles' A.J. Brown (hamstring) is out for Sunday's game against the Saints after missing practice all week. Brown's second straight absence will once again leave DeVonta Smith as the No. 1 receiver for Jalen Hurts, a role the speedster posted a 7-76-1 line in during a Week 2 Monday night loss to the Falcons. In turn, Jahan Dotson and Britain Covey are expected to bump up to the Nos. 2 and 3 receiver spots, respectively, while both running back Saquon Barkley and tight end Dallas Goedert could also see their involvement in the passing game rise. |
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| The 49ers' Deebo Samuel (calf) is out for Sunday's game against the Rams after missing practice all week. In Samuel's absence, Brandon Aiyuk will step into the No. 1 receiver role, while veteran Jauan Jennings will bump up a spot on the depth chart to No. 2. Samuel's lack of availability coupled with the confirmed absences of tight end George Kittle (hamstring) and Christian McCaffrey (IR-calf/Achilles) rob quarterback Brock Purdy of three potent and versatile pass-catching weapons and downgrade the entire outlook for San Francisco's air attack. |
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| The Rams' Cooper Kupp (ankle) is out for Sunday's game against the 49ers after missing practice all week. His absence, along with that of Puka Nacua (IR-knee), will conspire to vault veteran Demarcus Robinson to the No. 1 receiver role while Tyler Johnson and rookie sixth-round pick Jordan Whittington slot in as the Nos. 2 and 3 options, respectively. Given the amount of targets vacated by the unavailability of Los Angeles' top two wideouts, running back Kyren Williams and tight end Colby Parkinson should both continue seeing additional passing game opportunities as well versus San Francisco. |
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| The Vikings' Jordan Addison (ankle) remains out for Sunday's game against the Texans after missing practice for the second straight week. In the talented second-year pro's absence, Jalen Nailor, who recorded three receptions for 54 yards and a touchdown during Addison's Week 2 absence against the 49ers, should once again serve as the No. 2 receiver alongside Justin Jefferson, while Brandon Powell and Trent Sherfield rotate in behind him. |
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| The Bengals' Tee Higgins is off the injury report and ready for his season debut in Monday night's game against the Commanders after finishing the week with a full practice Saturday following a pair of limited sessions to open the week. As per Friday reports, Higgins declared himself back to full health and stated he'd already been feeling ready to play during Week 2 warmups before the Bengals faced the Chiefs. His return Monday night benefits top wideout Ja'Marr Chase, who should see less defensive attention, and bumps second-year pro Andrei Iosivas back down to a No. 3 role. |
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| The Colts' Michael Pittman (back/calf) is questionable for Sunday's game against the Bears after missing Friday's practice. As per Saturday night reports, Pittman is expected to suit up and handle his usual No. 1 receiver role versus Chicago. If he were to have a setback, Alec Pierce or the debuting Josh Downs would serve as the de facto top wideout for Anthony Richardson. |
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| The Bears' Keenan Allen (heel) has been ruled out for Sunday's game against the Colts after missing practice all week. In Allen's absence, rookie ninth overall pick Rome Odunze will fill the No. 2 role alongside DJ Moore and try to improve on the modest 3-44 line he's mustered in his first two career games. |
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| The Chargers' Joshua Palmer (elbow) is questionable for Sunday's game against the Steelers after missing practice all week. If Palmer is unable to suit up, Quentin Johnston, who's been a pleasant surprise through the first two games while recording an 8-89-2 line, would serve as the No. 1 wideout and rookie Ladd McConkey would bump up a notch to the No. 2 spot. However, who they'd be catching passes from remains up in the air leading up to pregame warmups, as Los Angeles could start any of Justin Herbert (ankle), Easton Stick or Taylor Heinicke according to early Sunday reports. |
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| The Colts' Josh Downs (ankle) is off the injury report ahead of Sunday's game against the Bears after practicing in full all week following back-to-back absences to open the season. Downs, who's expected to serve as the No. 2 receiver for Anthony Richardson, is fully recovered from the ankle injury he sustained in an early-August training camp practice and will begin his quest to build on the impressive 68-771-2 line he posted over 17 regular-season games as a rookie in 2023. |
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| The Broncos' Devaughn Vele is off the injury report for Sunday's game against the Buccaneers after putting in full practices Thursday and Friday following a Week 2 absence due to a rib injury. The rookie will slot back into the No. 3 receiver role behind Courtland Sutton and Josh Reynolds in his return. |
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| The Steelers' Roman Wilson is off the injury report for Sunday's game against the Chargers after finishing the week with consecutive full practices following back-to-back absences due to an ankle injury to open the season. The rookie third-round pick is expected to fill the No. 4 receiver role in his NFL debut against Los Angeles, bumping Scotty Miller down one spot on the depth chart. |
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| The Cardinals' Greg Dortch (hamstring) is questionable for Sunday's game against the Lions after turning in a limited practice Friday. As per early Sunday reports, Dortch is expected to play. If Dortch were to reverse course, veteran journeyman Chris Moore would be in line to serve as the No. 3 receiver versus Detroit. |
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| The Browns' David Bell (hip) was placed on injured reserve Tuesday, ending his season. In his absence the rest of the way, Cedric Tillman is expected to serve as Cleveland's No. 4 receiver beginning with Sunday's game against the Giants. |
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| The Cowboys' Jalen Brooks (ankle) is questionable for Sunday's game against the Ravens after practicing in limited fashion both Thursday and Friday. If Brooks is unable to suit up, KaVontae Turpin would move into the No. 4 receiver role for Dallas versus Baltimore. |
