Gardner Minshew led the Colts to another victory last Sunday, Indianapolis' third consecutive win. Minshew and the Colts will go for their fourth straight when they visit Derrick Henry and the Tennessee Titans in an AFC South showdown on Sunday. The Titans snapped a three-game losing streak with a 17-10 victory over the Panthers and have won five of their last six meetings against the Colts. According to the latest Week 13 NFL odds via the SportsLine consensus, the Titans are one-point underdogs at home. Should your Week 13 NFL picks include backing the Titans to cover the spread, or are you better off targeting other NFL underdogs like the Eagles (+3) at home against the 49ers? All of the Week 13 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and NFL predictions you need to make the best Week 13 NFL picks now.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 13 of the 2023 NFL season on an incredible 175-126 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 29-18 roll on top-rated NFL picks since Week 7 of last season and is 22-8 straight-up the last two weeks.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, it has turned its attention to the latest Week 13 NFL odds and locked in picks for every NFL matchup. Head here to see every pick.

Top Week 13 NFL predictions

We can tell you one of the model's strongest Week 13 NFL picks is that the Buccaneers (-3.5) cover at home against the Panthers. Carolina hoped to reverse its fortunes following a 7-10 season in which the Panthers won four of their last six games, bringing in former Colts head coach Frank Reich and then trading up to select Bryce Young with the No. 1 overall pick in the 2023 NFL Draft.

However, Young has struggled considerably in his rookie season and Reich was fired after a 1-10 start. Now, they'll take on a Buccaneers squad that is still alive in the NFC South title race. Tampa Bay is 7-4 against the spread this season, while Carolina is 2-8-1 against the number and has only covered once on the road this season. Those are big reasons why the model has the Buccaneers covering in 60% of simulations. See which other teams to pick here.

Another one of its Week 13 NFL predictions: The Jaguars (-9.5) cover the spread at home versus the Bengals on Monday. The Jaguars are in the hunt for the No. 1 overall seed in the AFC for good reason. Jacksonville's offense is averaging 344.2 yards and 23.1 points per game this season. The Jaguars have a plethora of playmakers at Trevor Lawrence's disposal, including wide receiver Calvin Ridley, who's scored three touchdowns over his last two games.

The Bengals, meanwhile, were stagnant on offense without Joe Burrow under center. In Jake Browning's first start for Cincinnati, the Bengals managed just 222 total yards in last week's loss against the Steelers. SportsLine's model is predicting the Jaguars will hold the Bengals to 14 points at home, a big reason why Jacksonville covers the spread in well over 50% of simulations. See which other teams to pick here.

How to make Week 13 NFL picks

The model has also made the call on who wins and covers in every other game on the Week 13 NFL schedule and just revealed three highly-coveted A-rated picks. You can only get every pick for every game at SportsLine.

So what NFL picks can you make with confidence, and which A-rated picks should you lock in now? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $7,000 since its inception, and find out.

Week 13 NFL odds, lines, spreads

Get full NFL picks at SportsLine

Sunday, Dec. 3

Chargers at Patriots (+5, 39)

Lions at Saints (+4.5, 47.5)

Falcons at Jets (+2, 33.5)

Cardinals at Steelers (-6.5, 41)

Colts at Titans (+1, 42.5)

Dolphins at Commanders (+9, 49.5)

Broncos at Texans (-3, 47.5)

Panthers at Buccaneers (-3.5, 36.5)

49ers at Eagles (+3, 47.5)

Browns at Rams (-4, 40.5)

Chiefs at Packers (+6, 42.5)

Monday, Dec. 4

Bengals at Jaguars (-9.5, 39.5)