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The Las Vegas Raiders (2-2) hit the road to take on the Denver Broncos (2-2) in an AFC West rivalry game on Sunday at Empower Field at Mile High. The Broncos are coming off a 10-9 road win over the New York Jets, and have won two straight after opening the season 0-2. The Raiders are coming off a 20-16 win over the Cleveland Browns. The Raiders have won eight straight games in this rivalry, and lead the all-time series 73-54-2. 

Kickoff in Denver is scheduled for 4:05 p.m. ET. The Broncos are favored by 2.5 points in the latest Broncos vs. Raiders odds from SportsLine consensus, and the over/under is 36 points. Before locking in any Raiders vs. Broncos picks, you'll want to see the NFL predictions and betting advice from the proven computer simulation model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 5 of the 2024 NFL season on an incredible 188-131 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 42-23 roll on top-rated NFL picks since Week 7 of 2022. The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

The model has set its sights on Broncos vs. Raiders and just locked in its picks and NFL Week 5 predictions. You can head to SportsLine now to see the model's picks. Here are several NFL odds and betting lines for the spreadmoney line and over/under:

  • Broncos vs. Raiders spread: Broncos -2.5
  • Broncos vs. Raiders over/under: 36 points
  • Broncos vs. Raiders money line: Broncos -152, Raiders +128
  • Broncos vs. Raiders picks: See picks at SportsLine
  • Broncos vs. Raiders streaming: FuboTV (try for free)

Why the Broncos can cover

The Broncos have been one of the best defensive teams in the NFL in 2024. Through four games, the Broncos rank second in total yards allowed per game (256.5) and third in both passing yards allowed per game (146.0) and points allowed per game (13.8). The Broncos also rank second in the NFL with 16 sacks. Outside linebacker Jonathan Cooper leads the team with 3.0.

Rookie quarterback Bo Nix has experienced some growing pains to open the season but played turnover-free football in the team's two wins. His top target has been veteran wide receiver Courtland Sutton, who has 15 catches for 192 yards and a touchdown. See which team to pick here

Why the Raiders can cover

The Raiders have won eight straight games against the Broncos. The Raiders have been streaky on the defensive side of the ball in 2024, but they do have one of the league's best groups of pass rushers. All-Pro Maxx Crosby (3.0 sacks) is a NFL Defensive Player of the Year candidate, though he is questionable with an ankle injury. If he's limited or can't go, his supporting cast including Charles Snowden, Christian Wilkins and Tyree Wilson, is strong.

The Raiders have also been streaky on the offensive side of the ball, but remain a group that is capable of erupting on any given Sunday. Rookie tight end Brock Bowers has the look of a future All-Pro. The first-round pick out of Georgia has 20 catches for 216 yards through four games. See which team to pick here

How to make Raiders vs. Broncos picks

The model has simulated Broncos vs. Raiders 10,000 times and the results are in. The model is leaning Over on the point total, and it's also generated a point-spread pick that hits in over 60% of simulations.. You can only see the model's pick at SportsLine.

So who wins Broncos vs. Raiders in Week 5, and which side of the spread cashes over 60% of the time? Visit SportsLine now to see which side of the Raiders vs. Broncos spread to back, all from the model that has returned well over $7,000 on top-rated NFL picks, and find out.