Warner (ankle) is not expected to return to practice this week, Mike Garafolo of NFL Network reports.
Warner has been sidelined since suffering a dislocated and fractured right ankle in Week 6, and there has been some hope that he could make his return to action in the postseason. The 49ers knocked off the Eagles 23-19 in the wild-card round Sunday, but head coach Kyle Shanahan said following the game that it's "not likely" that Warner's practice window will open this week prior to the team's matchup with the Seahawks in the NFC divisional round. The linebacker's next shot to play would come in the NFC Championship Game, if San Francisco is able to advance.
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49ers' Ji'Ayir Brown: Done for night
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Brown (hamstring) has been ruled out for the remainder of Sunday's contest against Philadelphia, Nick Wagoner of ESPN.com reports.
Brown suffered a hamstring injury late in the first half, and his night has now officially come to a premature end. Marques Sigle will continue to see an increase in workload in San Francisco's secondary with Brown unavailable.
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49ers' Ji'Ayir Brown: Dealing with hamstring injury
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Brown (hamstring) is questionable to return to Sunday's contest against the Eagles, Eric Branch of the San Francisco Chronicle reports.
Brown suffered a hamstring injury in the second quarter of the team's matchup with Philadelphia in the wild-card round. In his absence, Jason Pinnock and Marques Sigle are top candidates to see added snaps at safety.
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49ers' Keion White: Will play versus the Eagles
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White (groin/hamstring) is active for Sunday's wild-card game versus Philadelphia.
White has dealt with groin and hamstring injuries during practice this week, but he increased his activity to participate in a limited fashion Friday. The 26-year-old has seen heavy playing time as a rotational pass rusher in 2025, tallying 12 tackles and 5.0 sacks across nine regular-season games with the 49ers.
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49ers' Renardo Green: Good to go for wild-card contest
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Green (ankle) is active for Sunday's wild-card matchup versus the Eagles.
Green popped up with an ankle injury during practice Friday, but he'll suit up and retain his starting spot at cornerback. The 2024 second-rounder tallied 60 tackles and 10 passes defended over 14 regular-season appearances this year.
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49ers' Dee Winters: Won't play versus Philly
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Winters (ankle) is inactive for Sunday's wild-card contest versus the Eagles.
Winters' status was up in the air after he sustained an ankle injury during the loss to Seattle in the regular-season finale. The 25-year-old will miss Sunday's contest along with San Francisco's other starting outside linebacker Luke Gifford (quadriceps), who was also injured during Week 18. In their absence, Curtis Robinson and Garret Wallow should start alongside middle linebacker Eric Kendricks.
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49ers' Luke Gifford: Won't play in wild-card round
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Gifford (quadriceps) is inactive for Sunday's wild-card game versus the Eagles.
Gifford suffered a quad injury during the Week 18 loss to Seattle. He and fellow starting outside linebacker Dee Winters (ankle) will now both be sidelined for Sunday's contest. In their absence, expect Curtis Robinson and Garret Wallow to both start alongside middle linebacker Eric Kendricks.
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49ers' Bryce Huff: Records four sacks with SF
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Huff appeared in 15 games for the 49ers in 2025 and finished the regular season with 30 tackles (14 solo), 4.0 sacks and two forced fumbles.
Huff was dealt to San Francisco after struggling to fit in with Philadelphia after signing a three-year contract with the Eagles in 2024. The pass-rush specialist couldn't sniff his previous career high of 10.0 sacks, but the 4.0 he recorded with the 49ers checked in as his second-highest mark through six years in the league. Huff remains under contract for the 2026 campaign, but he doesn't provide enough upside as an IDP option in fantasy when he only sees the field on passing downs.
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49ers' Deommodore Lenoir: Logs over 1,000 snaps on defense
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Lenoir finished the 2025 regular season with 61 tackles (39 solo) and two interceptions across 17 starts.
Lenoir turned in another strong campaign as a shutdown coverage corner for the 49ers, but his IDP numbers took a slight dip in 2025. The 61 tackles registered as his lowest total in the four full seasons he has been a starter in the pros (averaged 82.7 last three years). The 25-year-old was rewarded with a lucrative five-year contract extension this past offseason, so expect Lenoir to continue operating as San Francisco's CB1 in 2026.
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49ers' Malik Mustapha: Strong return from surgery in 2025
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Mustapha logged 76 combined tackles (44 solo) and defended three passes (including one interception) across 12 regular-season starts in 2025.
Mustapha opened the regular season on the PUP list after undergoing successful surgery on the knee he injured at the tail end of the 2024 campaign. The sophomore safety missed only one game past the minimum four-week requirement and looked as dominant as he did prior to tearing his ACL. Mustapha reclaimed his starting strong safety job in Week 6 and still surpassed last year's tackle total (72) despite appearing in four fewer games. Following the 49ers' playoff run, the 23-year-old will attempt to combine good health with continued strong play while starting alongside Ji'Ayir Brown in 2026.
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49ers' Renardo Green: Questionable with ankle issue
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Green (ankle) is listed as questionable for Sunday's wild-card round matchup with the Eagles.
Green was added to Friday's injury report with what was initially rumored to be a foot injury, but the issue is actually with his ankle. The starting cornerback was able to log a limited practice session with the issue, something that bodes well for his chances to play in Sunday's elimination game. If Green is unable to play through injury, Darrell Luter is next in line to start Sunday's game at outside cornerback opposite Deommodore Lenoir.
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49ers' Keion White: Questionable for Sunday
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White (groin/hamstring) is listed as questionable ahead of Sunday's wild-card matchup with the Eagles, Noah Furtado of the San Francisco Chronicle reports.
White was able to upgrade to a limited participant in Friday's practice after missing consecutive sessions due to groin and hamstring issues. If the defensive end is unable to suit up for Sunday's elimination game, Robert Beal will likely see an increase in rotational defensive snaps as well as special-teams snaps.
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49ers' Renardo Green: Pops up on report with foot injury
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Green (foot) is listed as questionable for Sunday's wild-card road game against the Eagles, Matt Maiocco of NBC Sports Bay Area reports.
Green was added to the injury report Friday as a limited participant after practicing without limitations Wednesday and Thursday. If Green is unable to take part in Sunday's playoff matchup, Darrell Luter would likely draw the start at outside cornerback opposite Deommodore Lenoir.
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49ers' Luke Gifford: Questionable for wild-card round
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Gifford (quadriceps) is listed as questionable for Sunday's wild-card game against the Eagles, Matt Maiocco of NBC Sports Bay Area reports.
Gifford and Dee Winters (ankle) both got hurt in Week 18 against the Seahawks, leaving each of San Francisco's starting outside linebackers questionable for Sunday's playoff matchup. Eric Kendricks, Curtis Robinson and Garret Wallow are the only remaining healthy options in the 49ers' injury-riddled linebacking corps.
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49ers' Dee Winters: Questionable to face Philly
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Winters (ankle) is listed as questionable for Sunday's wild-card road game against the Eagles, Matt Maiocco of NBC Sports Bay Area reports.
Winters and Luke Gifford (quadriceps) are both questionable, leaving the status of San Francisco's linebacker corps in flux. Both starting outside linebackers were injured in Week 18 against the Seahawks, and Winters was subsequently unable to practice in any capacity throughout the week. Curtis Robinson and Garret Wallow would be the next men up at the position flanking Eric Kendricks.
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49ers' Ji'Ayir Brown: Moves to strong safety in 2025
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Brown had 76 tackles (44 solo), two interceptions and one forced fumble in 17 regular-season starts with the 49ers in 2025.
Brown's versatility was on full display in 2025 when he was asked to move over to strong safety in Week 6 after teammate Malik Mustapha returned from injury. The 25-year-old Brown wasn't affected by the shift when he finished the regular season with one less combined tackle and one more interception than he did in 2024. Brown will enter the final year of his rookie contract starting at one of San Francisco's safety positions while providing a solid floor for IDP fantasy managers.
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49ers' Upton Stout: Takes over as slot CB in first year
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Stout finished with 82 tackles (43 solo), 1.0 sacks and one forced fumble across 16 regular-season games in 2025.
Stout was selected in the third round of the 2025 NFL Draft and was inserted as the 49ers' starting slot corner right out of the gate. The 23-year-old suffered from the occasional blown coverage, but the overall results were positive given the prominent role he was asked to fill as a rookie. The 82 combined tackles stand out from a fantasy perspective, especially considering he only saw the field in nickel or lighter formations. Stout should only improve with experience now that he solidified himself as the team's starting slot cornerback for the 2026 season.
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49ers' Fred Warner: Seen running Thursday, still on IR
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Warner (ankle) was seen sprinting on the side during Thursday's practice, Matt Barrows of The Athletic reports.
Warner has been on injured reserve since hurting his ankle in Week 6 and has already been ruled out for Sunday's wild-card-round game against the Eagles, but he's progressing in his recovery, and Barrows speculates that Warner could be an option to return as soon as the NFC divisional round if the 49ers advance. Getting the four-time Pro Bowler back would be a huge boost to a 49ers defense that has been decimated by injuries at linebacker. Tatum Bethune (groin) and Nick Martin (concussion) are on IR alongside Warner, while Dee Winters (ankle) and Luke Gifford (quadriceps) are uncertain to be available against the Eagles.
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49ers' Keion White: Not practicing Wednesday
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White (hamstring) won't participate in practice Wednesday, Matt Barrows of The Athletic reports.
White likely tweaked his hamstring in the 49ers' loss to the Seahawks in Week 18, though it's unclear when the injury would have occurred, as the 26-year-old maintained his usual snap share (39 on defense and five on special teams). The third-year pro will need to upgrade to limited or full participation in practice through the rest of the week to have a chance at playing in the wild-card matchup against the Eagles.
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49ers' Dee Winters: Not practicing Wednesday
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Winters (ankle) did not practice in Wednesday's session, Matt Barrows of The Athletic reports.
Winters sustained an ankle injury in last Saturday's loss to the Seahawks, and the weakside linebacker's playoff status is now in jeopardy. The 25-year-old will have two more opportunities to increase his practice participation in an attempt to dodge any injury designation ahead of Sunday's playoff game against the Eagles. If Winters cannot suit up, the 49ers' linebacker corps, which typically consists of eight players, will be down to just four at most. Linebacker is the most likely position to be elevated from the practice squad for the 49ers on Saturday.
